Active Ingredient: Sildenafil Citrate
Treatment: Erectile Dysfunction
Country of Manufacture: Multinational, United States
Avigra Tablet Image
Review and Description
Avigra is one of the first generic sildenafil formulas that sought to fill the shoes of Viagra, by bringing commensurate relief to patients suffering from erectile dysfunction or impotence at a comparatively affordable price. Avigra comes in three formulations namely: Avigra 25, Avigra 50 and Avigra 100. 25 milligrams, 50 milligrams and 100 milligrams respectively. They each contain Sildenafil citrate as the main active ingredient – an ingredient that is necessary for relaxing smooth muscles of the penis and thereafter spurring increased blood flow. This is done, in vivo, by Sildenafil when it halts the breakdown of cyclic guanosine monophosphate by phosphodiesterase type 5. Halting said breakdown releases more cGMP to carry out the process of relaxing smooth muscles with a view to expanding the blood vessels of the region; an expansion that increases blood flow, and by extension, firmness of erections.
it is interesting that Avigra is developed, produced and circulated by American Multinational pharmaceutical giant Pfizer. This company is one that needs no introduction, certainly not in the category of erectile dysfunction treatment. It is Pfizer’s R&D facility in England, after all, that produced and patented the Ubiquitous brand Viagra in 1996. Following FDA approval two years later, Viagra became the first oral treatment for erectile dysfunction. Founded in 1849 by Charles Pfizer and Charles F. Erhart, the company is headquartered in New York City and has grown through mergers, acquisitions and scandal (see the Bextra debacle) to become the fourth largest pharmaceutical company of any kind in the world. Pfizer has managed to achieve this admirable level of success by specialized operations in oncology, emerging markets, established products, primary care, consumer healthcare, specialty care, nutrition, animal health and capsugel.
As is expected for almost every other Pfizer offering, we were successful in tracing out customer reviews. The reviews were mostly positive for Avigra which is pretty much the norm for this manufacturer and comes as no surprise given their aforementioned history with erectile dysfunction treatment. While we would normally share said reviews here with you, we have chosen instead to highlight a patient report which was forwarded to the Food and Drug Administration for concerns arising from Avigra use.
The report is for a 66-year-old male patient who lives in New Zealand and was treated with Avigra using an average dosage of 8x100mg per month. The patient was hospitalized after experiencing Carpal Tunnel Syndrome and Paraesthesia. There are also reports of Renal impairment, Hypotension, Supraventricular Tachycardia and Cerebral Infarction associated with Avigra use. Association, however, does not equal causation.
Pricing and Dosage
Avigra is synthesized in diamond blue film-coated tablets of 25mg, 50mg and 100mg, and is marketed in corresponding packs of four tablets labeled Avigra 25, Avigra 50 and Avigra 100. The screen grab above indicates the price for the fifty milligrams tablets.
Here, we have four tabs of Avigra for one hundred dollars and twelve tabs available for 197 US dollars. This suggests that the price decreases with incremental amounts of pills. While this is more expensive than most other generic sildenafil, it is cheaper than Viagra which sells 30 pills at a rate of $24.83 a pill.
The recommended dosage is one tablet once daily.
How to Buy Avigra Online
The ease with which you can get Avigra online is certainly a factor of this manufacturer’s enduring popularity with the buying public. Avigra is widely available on the internet, which makes placing orders for required amounts of the medicine a pleasant experience. You can order Avigra on a variety of online drug stores for prices similar to those we described above. You will find that the prices for each of the three formulations of this drug are higher than those of generic competitors. Shipping information varies from website to website and this medicine is only obtainable after presenting a prescription.
How to Use
Avigra’s film-coated tablets should be taken orally with the help of a glass of plain water. Mastication before ingestion should be avoided since that could decrease effectiveness. Also, if taken close to a meal – in particular meals including alcoholic beverages, grapefruit juice or fat-rich foods -the onset of the activity may be delayed. The recommended dosage is 50 milligrams and could be increased to 100 milligrams or decreased to 25 milligrams depending on toleration. This medicine is for male ED treatment and shouldn’t be used by females and children.
Adverse effects reported with relative frequency and of which manifestations are relatively less severe include headaches, flushing, dyspepsia, nasal congestion, back pain, dizziness and diarrhoea. There are yet other side effects which occur with markedly lower frequency and are a bit more severe. These include peripheral oedema, oedema, face oedema, insomnia, contact dermatitis, exfoliative dermatitis, paraesthesia and tachycardia. See a doctor for this group of adverse effects.
Conclusion with Rating
Avigra 25, Avigra 50 and Avigra 100 are just three of several generic sildenafil medicines and/or formulations that Pfizer introduced into the market around the time their Viagra patent expired to continue their revolutionary journey in erectile dysfunction medicines. Avigra was created to be marketed in New Zealand at a much more affordable price than its patented predecessor. Since its introduction in 2011, the drug has accumulated a substantial amount of positive customer reviews even though the drug’s popularity pales considerably compared with Viagra. We opted, however, to highlight the few reports of severe adverse effects in order to convey a balanced view of the drug. Avigra treatment was otherwise well tolerated in clinical trials. A household name, Pfizer has accumulated overwhelmingly positive reviews for their ever evolving, ever growing catalog of prescription and generic medications over the course of one-hundred and sixty-eight years in the pharmaceutical industry. The fact that this multinational enterprise patented the first oral treatment for ED cannot be overemphasized. As far as generics go Avigra is a modest winner only due to its initial confinement to the New Zealand market. We confidently rate Avigra 3 stars out of 5. It is prescription-only so consult your doctor.